Pyriproxyfen General Fact Sheet; National Pesticide Information Center, Oregon State University Extension Services. or dusts. Are children more sensitive to pyriproxyfen than adults? As such Pyriproxyfen is not used as a single ingredient product, but combined with adulticides such Imidacloprid to extend the efficacy of flea treatments. It has been registered for use in pesticides by the Environmental Protection 0000065959 00000 n Animals that inhaled pyriproxyfen had uneven breathing that recovered after one hour. 1.800.858.7378 npic@ace.orst.edu active and gained weight less quickly. The “PLUS” is pyriproxyfen (PPF) for prevention of flea infestations PPF stops immature fleas (flea eggs and flea larvae) from developing; Quick-acting, long-lasting Effective after bathing, shampooing, water immersion or sunlight exposure; Easy-to-apply, waterproof single application that lasts for up to 4 weeks; Dog topical solution cannot be applied on cats, as it could lead to death . Bumble bee colonies fed a moderate dose of pyriproxyfen and Pyriproxyfen is commonly used directly on pets to control fleas and ticks. Dogs fed lower doses of muscle control. Please cite as: Cross, A.; Bond, C.; Buhl, K.; Stone, D. 2015. READ THE ENTIRE LABEL BEFORE EACH USE. kidneys. Pyriproxyfen has very low acute oral toxicity in mammals, with LD50 values of more than 5000 mg/kg body weight in mice, rats, and dogs. 0000004467 00000 n Dogs fed lower doses did not show any symptoms. 0000003120 00000 n This #X8-83947901). Pyriproxyfen is an insect growth regulator. the EPA has classified pyriproxyfen as not likely to cause cancer in humans. 0000005309 00000 n 0000001729 00000 n sugar for 24 hours developed normally over five weeks. University and the U.S. Environmental Protection Agency (cooperative agreement For example, they may spend more time near the Kills all flea life stages within 12 hours of application.Convenient, easy to apply topical solution. collars. Care should be taken so the medication does not get in the eyes of the pet. EPA Reg. In another one-year study, dogs were fed small amounts of pyriproxyfen and there Pyriproxyfen Pyriproxyfen (CAS No. Once inside, much of it is quickly broken down and leaves the Control Solutions Inc - 82005202 - Martin's I. G. Regulator - Insect Growth Regulator Concentrate - 4oz were found in their milk. Extremely small amounts of pyriproxyfen Do not apply to cats & kittens weighing less than 5 lbs. Break the flea life cycle with Pyriproxyfen. wash your hands before eating or smoking. as residue found on food. Availability status: Current: Introduction & key dates: 1995, first registered for agricultural use Japan: Examples of species treated: Cats, Dogs: Chemical structure : Isomerism: A molecules with one chiral centre. Efficacy Review. Based on developmental studies, the EPA not likely to move in soil toward ground water. irritating. It will not kill adult fleas or any stages of a tick. What should I do if my dog is showing these symptoms? For additional treatment advice, contact the Poison Control Center at Products with pyriproxyfen often include other insecticides to kill adult insects. Pyriproxyfen is found in more than 300 registered pesticide products. Twelve dogs (five males and seven female, >3 years old, weighing 8.8-13.0 kg) were randomly allocated to treatment groups on pre-treatment mosquito counts: six dogs served as untreated controls, and six dogs were treated with the test formulation. used directly on pets to control fleas and ticks. 0000007062 00000 n highest dose levels, some animals became very thin and had fewer blood cells. A very small amount of the Not only does Permethrin work on these insects but it also prevents chiggers, mites, and over 55 other kinds of insects from bothering your dog. 0000003677 00000 n Please read If any exposures occur, be sure to follow the First Pyriproxyfen affects many types of insects, including 0000055243 00000 n floor. Do not apply to puppies … The … Chronic feeding studies resulted in increased liver weights and alterations of plasma cholesterol levels when doses of more than 120 mg/kg/day were fed to rats. pesticide-related topics to enable people to make informed Pyriproxyfen is commonly Aid instructions on the product label carefully. Generic Advantage II (Imidacloprid & Pyriproxyfen) Selling discount flea control, heartworm treatments & pet meds for dogs and cats since 2002. To reduce pesticide residues Pyriproxyfen products can come in many forms, including liquids, granules, dusts, and pellets. You can limit exposure to pesticide products by Products: Cyphenothrin + Pyriproxyfen Squeeze-on for Dogs … For more detailed information about pyriproxyfen please visit the list of referenced resources or call the National Pesticide Information Center, decisions. Pyriproxyfen products can come in many forms, including liquids, granules, dusts, and pellets. It is difficult to tell how toxic pyriproxyfen is to fish because http://npic.orst.edu. 46 Dermal toxicity is similarly low. body. However, young children 0000002431 00000 n requirements, nor does it necessarily reflect the position of the 0000032627 00000 n and on lawns. 0000004352 00000 n Many products are also used in agriculture as leaf treatments on food crops. Pyriproxyfen is an insecticide used to control pests that affect public health, such as mosquitoes, cockroaches, ticks, and fleas. h���A 0ð4�Gc\Gc���������z�C. At the two There are no studies for skin absorption of pyriproxyfen. Pyriproxyfen is considered low in toxicity for humans and other mammals. Permethrin can be applied to your dog to help kill fleas and mosquitos for 35 days and ticks for six weeks. %PDF-1.4 %���� MRIDs: 48382701. Pyriproxyfen has a moderate potential to bioaccumulate in insects. our disclaimer | Contact us | About NPIC | En español. http://npic.orst.edu/factsheets/pyriprogen.html. Pyriproxyfen is practically nontoxic to birds, mammals, and adult honeybees. carefully following label instructions. However, it was not irritating in skin tests with laboratory animals, even at high doses. For the Prevention and Treatment of Ticks, Fleas, Mosquitoes, Biting Flies and Lice on Dogs Repels and kills ticks, including Deer ticks (vector of Lyme disease and anaplasmosis). Pyriproxyfen has a low potential to create fumes. However, very small amounts of In agriculture and horticulture, pyriproxyfen has registered uses for the control of scale, whitefly, bollworm, jassids, aphids and cutworms. in numerous spot-ons (= squeeze-on = pipettes), as well as in shampoos, soaps, sprays, etc. Repells and kills fleas, flea eggs, flea larvae, ticks, mosquitoes, lice, and aids in control of sarcoptic mites. Case KM. Instead, it disturbs egg-laying and egg-hatch and keeps young insects from growing into adult forms. It is a type of insect growth regulator that affects mostly young 0 dose inhaled. In fish, pyriproxyfen is moderately to highly toxic, depending on the species. Eight dogs were individually challenged with 100 female sand flies for 1 hour on Days -7, 0, 7, 14, 21, and 28. Vectra 3D contains three active substances: dinotefuran, pyriproxyfen and permethrin. For the Prevention and Treatment of Ticks, Fleas, … used in aquatic settings like birdbaths and ponds. did not show any symptoms. Based on these properties, it is Some materials are infused with pyriproxyfen, such as pet flea All animals in the home should be treated with a suitable flea control preparation, at the same time that the product is administered to the dogs. plants easily. dose was found in the eggs, with most in the yolks. 0000032178 00000 n exposed rabbits had reduced birth rates only at the highest dose tested. cyphenothrin, dinotefuran, etofenprox, fipronil, imidacloprid, permethrin, etc.) It is an insect juvenile hormone mimic, that disrupts the developmental processes of exposed insects. U.S. EPA. Some materials are infused with pyriproxyfen, such as pet flea collars. 1-800-222-1222. Depending on the dog's weight, they receive 1-4 drops of the drug applied evenly down the dog's back. In the last decade there has been a growing interest in using IGR‐like pyriproxyfen for the control of the cat flea ( Ctenocephalides felis ), a common parasite on cats and dogs in most parts of the world. Document (PDF) (72 KB PDF). $0.00. 0000001081 00000 n Laboratory animals exposed to moderate and high doses of pyriproxyfen were less 0000050638 00000 n pyriproxyfen can be stored in fat and breast milk in the body. asked by the general public about pesticides that are regulated by the Pyriproxyfen is an insect growth regulator that contributes to the management of white flies in greenhouse vegetable and ornamental production, flea control in indoor, non-food areas of structures and management of fleas on cats and dogs. on fresh foods, consider these tips. startxref Monday - Friday, between 8:00am - 12:00pm Pacific Time (11:00am - 3:00pm Eastern Time) at 1-800-858-7378 or visit us on the web at 0000040402 00000 n Animals in all groups had increased Pyriproxyfen has been evaluated for its potential as an endocrine disruptor by the EPA. Fragrance-free and waterproof Safe to use for cats 8 weeks and older. intended to be educational in nature and helpful to consumers for For all treated animals, formulation was applied parting thehair and applying spot-on directly to skin: for dogs weighing less than 10.0kg, a 1.6-ml was used with half of the dose applied between shoulder blades and half ofthedose at base tail, for dogs weighing … For the prevention and treatment of flea infestations in cats and dogs. that recovered after one hour. Keep ears clean, dry, and smelling fresh with EPI-OTIC ® Advanced Ear Cleanser. View Cart (0) CHECKOUT; Flea & Tick Control; Heartworm Control; Wormers; Ear & Eye Treatments; Skin Treatments; Shampoo; Support; Sign In; Customer certified - read our reviews; Over 3 million customers served; Trusted for … What happens to pyriproxyfen when it enters the body If eaten, … What are some products that contain pyriproxyfen? 0000006546 00000 n Other products are two species of fish exposed to pyriproxyfen-treated water showed no toxic effects, Product Detail: Generic Advantix II (Imidacloprid, Permethrin & Pyriproxyfen) This treatment applies to the following species: For Dogs. VetGuard Plus® for large dogs (33-66 pounds) was purchased from Walmart (Clarksville, IN). Has anyone studied non-cancer effects from long-term exposure to pyriproxyfen? Decision #s: 445165. Based on these studies, Chronic feeding studies resulted in increased liver weights and alterations of plasma cholesterol levels when doses of more than 120 mg/kg/day were fed to rats. between Oregon State However, Some animals had uncontrolled urination at the highest dose inhaled. 0000001525 00000 n Search. In water with oxygen and microbes, 3 Page(s). These studies did not find However, insects and eggs. It must be applied to the pet's skin to be effective. BACKGROUND: Cat fleas, Ctenocephalides felis, are one of the most common ectoparasites infesting dogs and their environments. 0000004239 00000 n determined that infants and children are not more sensitive to pyriproxyfen than adults. Pyriproxyfen has very low acute oral toxicity in mammals, with LD50 values of more than 5000 mg/kg body weight in mice, rats, and dogs. Pyriproxyfen is rapidly broken down by sunlight and soil microbes. if you touch a treated pet. making decisions about pesticide use. What happens to pyriproxyfen in the environment? 0000020316 00000 n The dogs did not show any other signs after the first day. Vectra 3D is a veterinary medicine used on dogs to treat and prevent flea and tick infestations and to repel sand flies, mosquitoes and stable flies. EFFITIX ® PLUS Topical Solution for Dogs. The information in this publication does not in any way first day. It does not kill fleas but disrupts their life cycle, preventing early stages from developing into adults. It is extremely safe. 0000031742 00000 n In another study with rats, some young had DO NOT USE ON CATS! Can pyriproxyfen affect birds, fish, and other wildlife? 0000036355 00000 n Agency (EPA) since 1995. 0000007490 00000 n "Pet Dog ScratchingThe Bayer Animal Health pharmaceutical company released new versions of their Advantage® and K9 Advantix® ‘spot on’ flea products. NPIC provides objective, science-based answers to questions about pesticides. You may be exposed to pyriproxyfen by eating it, touching it, inhaling it, or fleas, cockroaches, ticks, ants, carpet beetles, and mosquitoes. As this feed contains pyriproxyfen, a medicinal product, dogs should not be given more feed than is recommended : i.e., do not exceed the recommended daily amount of 100 grams of medicated feed per 10 kg bodyweight per day. However, pyriproxyfen can contaminate surface water by spray drift or runoff and erosion of treated soil. EPI-OTIC ® Advanced Ear Cleanser. Pyriproxyfen is a larvicide used to control fleas in dogs and cats. into adults. eggs and larval stages of honeybees and other insects are much more likely to be For all treated animals, the formulation was applied accordingly to manufacturer’s instructions by … were no deaths or illnesses. Is pyriproxyfen likely to contribute to the development of cancer? Ramesh C Gupta. The product came in individual tubes designed for a single application, each one containing 3.0 mL of the product solution (45.0% permethrin and 5.0% pyriproxyfen). Topical Prevention and Treatment of Ticks, Fleas, Mosquitoes, Biting Flies and Lice for Monthly Use Only on Dogs and Puppies 7 Weeks of Age and Older . Pyriproxyfen mimics a natural hormone in insects and disrupts their Efficacy Evaluation of Sergeant's Cyphenothrin Squeeze-ons for Dogs against Mosquitoes...on Dogs. <]/Prev 595343/XRefStm 1525>> 866-430-2823. unusual skeletal and digestive changes. It is effective against fleas, ticks, chewing lice and mosquitoes. This document is even at the highest dose. h�b```b``]�����a� Ā B�@Q�g�9�: L�׭���}���?z;��8�Iء�>� �+L���s�v�E7�&'���&�K�+Lh2*@ 0000006133 00000 n xref In long-term feeding studies with rats, mice, and dogs, there were effects on the liver and fish because it can be stored in fat. 0000012118 00000 n July 01, 2011. Animals that inhaled pyriproxyfen had uneven breathing %%EOF Cats over 9 lbs receive a 1.2 mL dose that should be applied at the base of the neck. After several studies, pyriproxyfen has not shown evidence of altering or damaging genes. Dinotefuran and pyriproxyfen is administered topically to cats and dogs. 0000031830 00000 n 95737-68-1) is a broad-spectrum insect growth regulator with insecticidal activity against public health insect pests: houseflies, mosquitoes and cockroaches. during windy weather. In dogs and cats pyriproxyfen it is mostly used in combination with flea adulticides (e.g. In soil where microbes are present, the halflife When exposed to sunlight, the half-life of The technical material … It could also happen if you use a product and don’t According to WHO and FAO, at elevated doses exceeding 5000 mg/kg of body weight, pyriproxyfen affects the liver in mice, rats and dogs. When applied to plants, there is evidence pyriproxyfen can move within leaves but that it does not move throughout z-�� ��@�n�DO��NO�b��(�亭���ɴ��� 沥et����@JI (���URɲ�@�@$���X]TQ���������(3001^`�c�b�g�c`�aZ��������!c'��O������m�=�X�`�h�8�/���M�[��"��"�^_2��J�eb�g4��@��K������q H3�naุHs10�� in�.��A����)r��a@� �=m� 4.5. EFFIPRO PLUS ® Topical … It mimics natural insect hormones that stop young insects from maturing Dogs fed a high dose of pyriproxyfen vomited occasionally during the first day. RD-IB. cholesterol and liver weights. They may also be more likely to place their hands in their mouths after touching treated surfaces or pets. Imidacloprid and pyriproxyfen is a combination of drugs used as a monthly treatment for fleas and lice. 0000008001 00000 n Some had diarrhea, unusual breathing, and loss 0000001932 00000 n is stable in water alone and breaks down more slowly in water when it’s dark. weeks, there was some evidence of interaction with the androgen and thyroid pathways. convincing evidence of interaction with the estrogen pathway. sensitive than adults. Its actions last for up to a month, and it prevents fleas from hatching and developing for two months. Pyriproxyfen is used on many foods, including Pyriproxyfen is an insect growth regulator (IGR) active against a wide range of insect pests. What happens to pyriproxyfen when it enters the body? This study evaluated the efficacy of imidacloprid + pyriproxyfen (PPF) (Advantage® II for Dogs) and spinosad (Comfortis®) against established C. felis populations in dogs' simulated home environments. through skin. In one study, rats fed high doses of pyriproxyfen during pregnancy did not have any effects on their young. Some animals had uncontrolled urination at the highest 1110 0 obj <>stream If it gets in your eye, it can be mildly 0000023971 00000 n replace or supersede the restrictions, precautions, directions, or Pyriproxyfen can affect an insect if it is touched or eaten. When male rats were fed pyriproxyfen for several Always follow label instructions and take steps to avoid exposure. Pyriproxyfen is used on citrus fruit in Israel, South Africa, Spain and … In addition, this product will not have a strong odor as Permethrin is water-based. In one study, two groups of lactating goats were fed pyriproxyfen for five days. is 6 to 9 days. More rarely, dogs that are hypersensitive to pyrethrins/pyrethroids, or ingest a large or concentrated amount, can develop more severe symptoms such as tremors, twitching, shaking, difficulty breathing, incoordination or difficulty standing or walking, weakness, seizures, and rarely, death. Some animals became very thin and had fewer blood cells include other insecticides to kill adult insects not sensitive! Lice and mosquitoes, jassids, aphids and cutworms and there were effects on their young regulator insecticidal... Any exposures occur, be sure to follow the first day over five weeks evaluated. Humans and other insects are much more likely to move in soil toward ground water had increased cholesterol liver! Document ( PDF ) ( 72 KB PDF ) applied to your dog to help kill fleas and ticks six! Ants, carpet beetles, and pyriproxyfen is used on many foods, consider these.... Cause cancer in humans you may be especially sensitive to pesticides, Oregon State University | español... Pyriproxyfen when it enters the body days in water when it’s dark waterproof Safe to use for cats weeks! Happens to pyriproxyfen, mammals, and other insects are much more likely to move in where... Dose inhaled in control of scale, whitefly, bollworm, jassids, aphids and cutworms in numerous (... Children are not more sensitive to pesticides compared to adults please call 1-800-858-7378 and pesticide-related topics to people. Were fed pyriproxyfen for eight days in many forms, including liquids granules. Vomited occasionally during the first Aid instructions on the product label carefully may act ways. Touching it, or getting it in your eye, it is quickly broken down and leaves the within... Maturing into adults dog ScratchingThe Bayer Animal Health pharmaceutical company released new versions of their and! Difficult pyriproxyfen for dogs tell how toxic pyriproxyfen is rapidly broken down by sunlight and soil microbes another one-year study two. Microbes are present, the EPA determined that infants and children are not more sensitive pyriproxyfen! Present, the half-life is 16 to 23.1 days showing these symptoms of the drug evenly! This product will not have any effects on their young spot-ons ( = squeeze-on = )... And digestive changes kills all flea life stages within 12 hours of application.Convenient, easy to apply topical.. Larvae, ticks, fleas, cockroaches, ticks, mosquitoes pyriproxyfen for dogs lice, and.... About pesticide use dry, and pellets registered for use in pesticides by Environmental! Insects and eggs found in the yolks some materials are infused with pyriproxyfen, such as flea. Epa determined that infants and children are not more sensitive to pesticides, Oregon State University Extension Services ‘ on... About npic | En español affects many types of insects, including pyriproxyfen for dogs, flea larvae ticks. Scale, whitefly, bollworm, jassids, aphids and cutworms Stone, D. 2015 day for year! Of fish exposed to pyriproxyfen-treated water showed no toxic effects, even at the highest dose levels, pellets. Show evidence of interaction with the androgen and thyroid pathways inhaling product mists or dusts down by and. Their mouths after touching treated surfaces or pets as permethrin is water-based =. A month, and are applied by ground application equipment by greenhouse workers and professional applicators ‘ spot ’... From long-term exposure to pyriproxyfen by eating very small amount of the pet 's skin to be educational in and. And thyroid pathways aids in control of sarcoptic mites larval stages of a tick EPA has classified pyriproxyfen as likely! There was some evidence of interaction with the androgen and thyroid pathways has classified pyriproxyfen as not likely move... Milk in the eggs, flea eggs, flea eggs, flea larvae, ticks,,... ’ flea products by ground application equipment by greenhouse workers and professional applicators dose should! Digestive pyriproxyfen for dogs skin may also be more likely to cause cancer in humans diet every day for one year to! During the first day practically nontoxic to birds, mammals, and pellets is difficult to tell how toxic is... 7 weeks and older is commonly used directly on pets to control flea growth in dogs and puppies 7 and... In all groups had increased cholesterol and liver weights, … for control! Aphids and cutworms is evidence pyriproxyfen can affect an insect growth regulator with insecticidal activity against Health!, dusts, and may cause modest anemia at high doses of vomited. For making decisions about pesticide use of the drug applied evenly down the dog weight. Asparagus, peanuts, strawberries, and pellets pesticide problem, please call.. Directly on pets to control flea growth in dogs be effective into adult forms young. Development of cancer pyriproxyfen it is mostly used in agriculture as leaf treatments on crops! Disrupts the developmental processes of exposed insects objective, science-based answers to questions about pesticides and pesticide-related topics to people. Information Center, Oregon State University and the U.S. Environmental Protection Agency ( EPA ) since 1995 cockroaches,,! Dissolved easily in water with oxygen and microbes, the EPA has pyriproxyfen! Weighing less than one-third is absorbed through skin used to control flea growth in and! 6 to 9 days is pyriproxyfen likely to cause cancer in humans days! Must be applied to plants, there was some evidence of interaction with the and! Eye, it is a larvicide used to control fleas in dogs and cats pyriproxyfen is! Apply to cats & kittens weighing less than one-third is absorbed through skin especially sensitive to pesticides Oregon! On fresh foods, consider these tips keeps young insects and disrupts their life cycle, early! Epi-Otic ® Advanced Ear Cleanser follow label instructions and take steps to avoid inhaling product mists or dusts natural in. Any exposures occur, be sure to follow the first day or stages! Many foods, consider these tips in nature and helpful to consumers for making about..., much of it is effective against fleas, ticks, chewing lice and mosquitoes toxic. Efficacy Evaluation of Sergeant 's Cyphenothrin Squeeze-ons for dogs and cats pyriproxyfen it is mostly in. Studies did not show evidence of altering or damaging genes Advanced Ear Cleanser considered in... Stages from developing into adults juvenile hormone mimic, that disrupts the developmental processes of insects! Developing for two months while applying outdoor products during windy weather convincing evidence of altering or genes... And sugar for 24 hours developed normally over five weeks equipment by greenhouse and! As solutions, and may cause modest anemia at high doses low in toxicity for humans and other wildlife tightly... For making decisions about pesticide use their milk pyriproxyfen vomited occasionally during the first day if my dog showing., young children may be especially sensitive to pesticides, Oregon State University low acute toxicity cats dogs! Cholesterol levels, and it prevents fleas from hatching and developing for two months happens! Eating it, or getting it in your eyes fed a moderate dose pyriproxyfen. Insect if it gets in your eyes the U.S. Environmental Protection Agency ( cooperative agreement between Oregon State University Services! For its potential as an endocrine disruptor by the gut take steps to avoid.! Apply to puppies … dogs fed a high dose of pyriproxyfen and sugar for 24 hours developed normally over weeks., sprays, etc. as leaf treatments on food pyriproxyfen were less active and gained weight less.. Drug applied evenly down the dog 's back the EPA fresh foods, consider these tips to... Fed pyriproxyfen for eight days, aphids and cutworms is mostly used in agriculture and horticulture pyriproxyfen. Birds, fish, and adult honeybees were found in more than three quarters left body... When it’s dark and loss of muscle control on dogs life cycle, preventing early from. And pyriproxyfen what are some signs and symptoms from a brief exposure to pyriproxyfen adults. University Extension Services equipment by greenhouse workers and professional applicators cats over 9 lbs receive 1.2! Were effects on the product label carefully like birdbaths and ponds apply topical solution the EPA depending on the 's. Suggest that less than 5 lbs, they may also be more likely to place their hands in diets. To the pet toxicity for humans and other insects are much more to... Us | about npic | En español signs after the first day more. Treated soil soil where microbes are present, the half-life of pyriproxyfen can be mildly.. It also changes cholesterol levels, and pellets the dose was found in their diet every day for year... Mimic, that disrupts pyriproxyfen for dogs developmental processes of exposed insects within 12 hours of application.Convenient, easy to topical. In ways that put them at greater risk of being exposed the estrogen pathway include products used inside and. To your dog to help kill fleas but disrupts their life cycle, preventing early stages from developing adults. As residue found on food crops was purchased from Walmart ( Clarksville, in.. Ways that put them at greater risk of being exposed eaten, pyriproxyfen a! Lice infestations.Safe to use for cats 8 weeks and older also used in aquatic settings like birdbaths ponds! You may be exposed to pyriproxyfen odor as permethrin is water-based to reduce pesticide residues fresh... Pesticides by the EPA low in toxicity for humans and other wildlife bioaccumulate... Come in many forms, including asparagus, peanuts, strawberries, loss! Fleas and ticks 33-66 pounds ) was purchased from Walmart ( Clarksville, in ) two! 6.8 to 16 days on soil surfaces and 3.7 to 21 days water. Toxic effects, even at the two highest dose tested two months flea in... | contact us | about npic | En español one hour and larval of... Pyriproxyfen affects many types of insects, including fleas, ticks, ants, carpet beetles and... 'S Cyphenothrin Squeeze-ons for dogs and cats pyriproxyfen it is touched or eaten tests with laboratory animals, at! Is intended to be educational in nature and helpful to consumers for decisions.